Fluidized processor for pharmaceutical application
Effective operation of fluidized bed processors requires a uniform gas distribution and good mixing of particles. Scaling up a fluidized bed process from lab scale to production-scale presents unique challenges such as preventing granule attrition, fines loss, or segregation. In addition, current methods make it difficult to optimize processor performance without large-scale experimentation due to the scale dependence of influences on the fluidization and related effects on the fluidized particle. Fluidization behavior is dependent on the reactor geometry and internals as well as the particle size distribution and physical properties of the powder. To accurately simulate fluidized bed behavior, it is necessary to choose a numerical method capable of accounting not only for the particle–fluid effects (e.g., drag) but also for particle–wall impacts and particle–particle interactions in three dimensions and across the entire particle size distribution.
The objective of this work was to perform a “blind test” comparison of the Barracuda® commercial computational fluid dynamics (CFD) software package from CPFD Software, LLC (Albuquerque, NM) for the modeling of fluidized bed processors.